The 2010 MMVAs had a cumulative average audience of 2.1 million viewers in the first 24 hours.
Gaga's third studio album, "Born This Way", will be released May 23, 2011.
The MMVAs are simulcast live in the US on Fuse, Madison Square Garden's national music television network.
Gaga's appearance follows last year's MMVA appearances by Miley Cyrus, Katy Perry, Drake and Justin Bieber.
"Canada's MMVAs have always been known for being the loudest live street party of the year," said Sheila Sullivan, Executive Producer, 2011 Muchmusic Video Awards.
Past MMVA presenters included The Black Eyed Peas, Rihanna, Britney Spears and Avril Lavigne.
Click the images to enlarge and Sneak Peek Lady Gaga's "Born This Way"...